Evaluating the effects of ocean acidification on fish and invertebrate stocks is an iterative and  multidisciplinary task. For crabs and fishes in the North Pacific, this has involved a decade-long collaboration between biologists, mathematical modelers, fishery managers, and economists and led to the development of a framework for conducting long-term population projections that help understanding likely effects of changes in ocean pH on catches, revenues and population sizes. This talk will summarize some of the past work and outline current research to more fully understand the consequences of uncertainty in estimates of model-based estimates on estimated changes in management reference points and how lab experiments used to assess the effects of ocean pH of population parameters could be refined / optimized to reduce uncertainty.